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Grapefruit Seed-Extract

Garnett Holloway

Date: 11/15/2005





What Does Grapefruit Seed Extract Do?

Grapefruit seed-extract is used in humans to battle many types of internal and external infections caused from single and multi-celled parasites, fungi, viruses, and bacteria (

The greatest benefit of grapefruit seed-extract is due to its multipurpose effect. Grapefruit seed-extract remains effective even if the cause of an infection is identified, misdiagnosed, or unknown. Grapefruit seed-extract naturally detoxifies, enhances and supports the immune system.

Another important benefit of grapefruit seed-extract is that it alkalizes the blood. Alkalizing body fluids can be defined as raising the pH level. Raising the pH level is an important health regeneration benefit; because disease causing microforms, such as parasites, fungi, viruses, and bacteria cannot survive in an alkaline oxygenated environment.


Grapefruit seed-extract is also claimed to be a natural alternative to strong antibiotics, without callous side effects (



How Does Grapefruit Seed-Extract Work?


Grapefruit seed-extract is made by converting grapefruit pulp and seeds into an extremely acidic liquid. The product is a bitter and acidic amber-colored liquid.


Grapefruit seed-extract exerts antibacterial, antifungal, and antioxidant activity due to naringenin.


Naringenin belongs to the class of flavanoids called flavanones. Flavanoids are naturally occurring molecules abundant in fruits, vegetables, seeds, and nuts. The pH level of naringenin in grapefruit seed-extract is a low 2.0 (Cardiovascular Drug Reviews 161).

Most degenerative diseases are associated with ones pH. Ones pH is an important aspect to consider when trying to overcome a serious illness and maintain good health. Most diseases cannot exist in an alkaline environment. The pH of a healthy person is 7.5.


Usage and Claims


Internal usage includes: Digestive upsets such as gastrointestinal disorders, diarrhea and food poisoning.

It can be used to fight parasitic, bacterial, viral and fungal infections.


External usage includes: Acne, ringworm, athletes foot, nail fungus, and bacterial, parasitic, and viral infections. It can also be applied to cuts and wounds.

Experiments to Support Claims


Grapefruit seed-extract is capable of preventing acute pancreatic damage induced by ischemia/reperfusion, which is known to result from reduction of anti-oxidative capability of pancreatic tissue. The study carried out on rats with acute hemorrhagic pancreatitis and, after reperfusion, with partial pancreatic ischemia. The grapefruit seed-extract was applied intragastically in gradual increasing amounts. Pretreatment with grapefruit seed-extract decreased the extent of pancreatitis with maximal protective effect of grapefruit seed-extract. Grapefruit seed-extract exerts protective activity against ischemia/reperfusion induced pancreatitus due to the activation of antioxidative mechanisms in the pancreas and the improvement of pancreatic blood flow (Journal of Physiology and Pharmacology 811).


Recent testimonials report grapefruit-seed extract, to be effective against more than 800 bacterial and viral strains, 100 strains of fungus, and a large number of single and multicelled parasites. It was evident that grapefruit seed-extract disrupts the bacterial membrane and liberates the cytoplasmic contents within 15 minutes after contact even at more dilute concentrations (Journal of Alternative and Complementary Medicine 521).


Another experiment was performed on the effectiveness to kill the bacteria salmonella. An aqueous solution of 0.1% and 0.5% grapefruit seed-extract was evaluated by spraying for reducing salmonella attached on chicken skins. The results showed that the numbers of salmonella on the chicken skins after the chemical spraying were significantly lower than those without spray (J Food Prot 272).


Another test of antibacterial and antifungal activity of grapefruit seed-extract was examined against 20 bacterial and 10 yeast strains. Grapefruit seed-extract produced the strongest antimicrobial effect against Salmonella. Other tested bacteria and yeasts were sensitive to extract concentrations (Acta Pharm 243).





Antiatherogenic Properties of Naringenin, a Citrus

FlavanoidCardiovascular Drug Reviews Volume 17, No. 2, pp. 160-178.  1999.  Neva Press, Branford,



Antimicrobial activity of grapefruit seed and pulp

ethanolic extract.  Acta Pharm. 2004 Sep;54(3):243-

50.Department of Microbiology, Faculty of Pharmacy and

Biochemistry, University of Zagreb, Croatia.


Extract of Grapefruit-Seed Reduces Acute Pancreatitis

Induced by Ischemia/Reperfusion in Rats; Possible

Implication of Tissue Antioxidants.  Journal of

Physiology and Pharmacology 2004, 55,4,811-821. 


Spraying Chicken Skin with Selected Chemicals to Reduce

Attached Salmonella Typhimurium. J Food Prot. 1998

Mar;61(3):272-5.Department of Biological & Agricultural Engineering, University of Arkansas, Fayetteville 72701, USA. 


The Effectiveness of Processed Grapefruit-Seed Extract as

An Antibacterial Agent: IIJournal of Alternative and Complementary Medicine.  Mechanism of Action

and In Vitro Toxicity Jun 2002, Vol. 8, No. 3: 333-340




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